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2019 Tshiab Style 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1

2019 Tshiab Style 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1

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CAS no: 376591-94-5

Cov khoom siv tshuaj: Eltrombopag Intermediates


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Khoom cim npe

Kev paub txog kev tswj hwm kev ua haujlwm ntau heev thiab tsuas yog ib qho rau ib tus neeg muab kev pabcuam tus qauv ua qhov tseem ceeb ntawm kev sib txuas lus hauv lub koom haum thiab peb txoj kev nkag siab yooj yim ntawm koj qhov kev cia siab rau 2019 Tshiab Style 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1, Peb txaus siab muab tus nqi qis tshaj plaws rau koj hauv kev ua lag luam, qhov zoo tshaj plaws thiab kev muag khoom zoo heev.Zoo siab txais tos ua bussines nrog peb, cia peb ua ob npaug.
Kev paub txog kev tswj hwm kev ua haujlwm ntau heev thiab tsuas yog ib qho rau ib tus qauv muab kev pabcuam ua rau qhov tseem ceeb ntawm kev sib txuas lus hauv lub koom haum thiab peb nkag siab yooj yim ntawm koj cov kev cia siab rauTuam Tshoj 3-Aminopyrazine-2-Carboxylic Acid thiab 5424-01-1, Peb cov khoom muaj npe nrov hauv lo lus, zoo li South American, Africa, Asia thiab lwm yam.Cov tuam txhab "tsim thawj cov khoom lag luam" raws li lub hom phiaj, thiab siv zog los muab cov neeg siv khoom nrog cov kev daws teeb meem zoo, muab cov kev pabcuam zoo tom qab muag thiab kev txhawb nqa kev pabcuam, thiab cov neeg siv khoom muaj txiaj ntsig, tsim kom muaj kev ua haujlwm zoo thiab yav tom ntej!

2′-Methoxy-3′-nitro-biphenyl-3-carboxylic acid yog siv los ua tus nruab nrab ntawm Eltrombopag.
Eltrombopag, tsim los ntawm GlaxoSmithKline (GSK) nyob rau hauv UK thiab tom qab ntawd koom ua ke tsim nrog Novartis hauv Switzerland, yog thawj zaug thiab tsuas pom zoo me me molecule tsis peptide TPO receptor agonist nyob hauv lub ntiaj teb no.Eltrombopag tau pom zoo los ntawm US FDA xyoo 2008 rau kev kho mob ntawm idiopathic thrombocytopenic purpura (ITP), thiab hauv 2014 rau kev kho mob hnyav aplastic anemia (AA).Nws kuj yog thawj cov tshuaj pom zoo los ntawm US FDA rau kev kho mob ntawm AA hauv 30 xyoo tsis ntev los no.
Thaum lub Kaum Ob Hlis 2012, US FDA tau pom zoo Eltrombopag rau kev kho mob ntawm thrombocytopenia rau cov neeg mob uas muaj kab mob siab C (CHC), kom cov neeg mob kab mob siab C uas muaj cov tsos mob tsis zoo vim qis platelet suav tuaj yeem pib thiab tswj hwm interferon raws li kev kho mob rau daim siab.Thaum Lub Ob Hlis 3, 2014, GlaxoSmithKline tshaj tawm tias FDA tau tso cai rau kev kho cov tshuaj kho mob uas tsim nyog ntawm Eltrombopag rau kev kho mob hemopenia hauv cov neeg mob uas muaj cov tshuaj lom neeg mob hnyav aplastic anemia (SAA) uas tsis tau teb tag nrho cov tshuaj tiv thaiv kab mob.Thaum Lub Yim Hli 24, 2015, US FDA tau pom zoo Eltrombopag rau kev kho mob thrombocytopenia hauv cov neeg laus thiab cov menyuam yaus hnub nyoog 1 xyoos thiab tshaj nrog cov kab mob tiv thaiv kab mob thrombocytopenia (ITP) uas tsis muaj cov lus teb tsis txaus rau corticosteroids, immunoglobulins lossis splenectomy.Thaum Lub Ib Hlis Ntuj Tim 4, 2018, Eltrombopag tau pom zoo kom muab teev rau hauv Suav teb rau kev kho mob thawj lub cev tiv thaiv kab mob thrombocytopenia (ITP).

Kev paub txog kev tswj hwm kev ua haujlwm ntau heev thiab tsuas yog ib qho rau ib tus neeg muab kev pabcuam tus qauv ua qhov tseem ceeb ntawm kev sib txuas lus hauv lub koom haum thiab peb txoj kev nkag siab yooj yim ntawm koj qhov kev cia siab rau 2019 Tshiab Style 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1, Peb txaus siab muab tus nqi qis tshaj plaws rau koj hauv kev ua lag luam, qhov zoo tshaj plaws thiab kev muag khoom zoo heev.Zoo siab txais tos ua bussines nrog peb, cia peb ua ob npaug.
2019 Tshiab StyleTuam Tshoj 3-Aminopyrazine-2-Carboxylic Acid thiab 5424-01-1, Peb cov khoom muaj npe nrov hauv lo lus, zoo li South American, Africa, Asia thiab lwm yam.Cov tuam txhab "tsim thawj cov khoom lag luam" raws li lub hom phiaj, thiab siv zog los muab cov neeg siv khoom nrog cov kev daws teeb meem zoo, muab cov kev pabcuam zoo tom qab muag thiab kev txhawb nqa kev pabcuam, thiab cov neeg siv khoom muaj txiaj ntsig, tsim kom muaj kev ua haujlwm zoo thiab yav tom ntej!


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