3-(1-(Dimethylamino)ethyl]phenol

3-(1-(Dimethylamino)ethyl] phenol yog siv los ua qhov nruab nrab ntawm Rivastigmine tartrate .
Rivastigmine tartrate yog rivastigmine Alzheimer's kab mob tshuaj, rivastigmine yog physostigmine derivative los ntawm Novartis thawj zaug ntse tsim lub npe lag luam Exelon (exelon), molecule nrog muaj carbamate qauv, yog ib yam ntawm cov amino acid ntawm xaiv cerebral cholinesterase inhibitor, kuj inhibitor. acetylcholinesterase thiab butyrylcholinesterase, cholinergic neurons los ntawm ncua kev tso tawm ntawm acetylcholine degradation thiab lub zog txhawb nqa cholinergic paj hlwb, tuaj yeem txhim kho kev paub txog kev ua haujlwm tsis zoo los ntawm cholinergic, yog li txhim kho kev paub txog kev ua haujlwm ntawm Alzheimer's cov neeg mob.Rivastigmine plasma protein binding tsis muaj zog, yooj yim los ntawm cov ntshav-hlwb barrier, uas muaj lub siab ntawm lub hlwb xaiv.Nws tsis tsuas yog xaiv tau yooj yim tshaj plaws cuam tshuam rau cerebral cortex thiab hippocampus, tab sis kuj nyiam inhibits qhov tseem ceeb ntawm AChE hauv lub hlwb, uas ua rau txo qis kev ua tau zoo ntawm peripheral cholinergic phiv.Rivastigmine hauv vivo ib nrab-lub neej yog luv thiab ntev ntawm kev ua.Tsis zoo li tacrine, cov khoom no nyob rau hauv hippocampus thiab cortex ntawm G1 enzyme inhibitory nyhuv muaj zog dua.Clinic rau kev kho mob me me mus rau nruab nrab Alzheimer-type dementia, lossis Alzheimer's disease tuaj yeem xav tias Alzheimer's kab mob hauv tsev kho mob.