3'-Amino-2'-hydroxy-[1,1'-bipheny]-3-carboxylic acid

3'-Amino-2'-hydroxy-[1,1'-bipheny]-3-carboxylic acid yog siv los ua qhov nruab nrab ntawm Eltrombopag.
Eltrombopag, tsim los ntawm GlaxoSmithKline (GSK) nyob rau hauv UK thiab tom qab ntawd koom ua ke tsim nrog Novartis hauv Switzerland, yog thawj zaug thiab tsuas pom zoo me me molecule tsis peptide TPO receptor agonist nyob hauv lub ntiaj teb no.Eltrombopag tau pom zoo los ntawm US FDA xyoo 2008 rau kev kho mob ntawm idiopathic thrombocytopenic purpura (ITP), thiab hauv 2014 rau kev kho mob hnyav aplastic anemia (AA).Nws kuj yog thawj cov tshuaj pom zoo los ntawm US FDA rau kev kho mob ntawm AA hauv 30 xyoo tsis ntev los no.
Thaum lub Kaum Ob Hlis 2012, US FDA tau pom zoo Eltrombopag rau kev kho mob ntawm thrombocytopenia rau cov neeg mob uas muaj kab mob siab C (CHC), kom cov neeg mob kab mob siab C uas muaj cov tsos mob tsis zoo vim qis platelet suav tuaj yeem pib thiab tswj hwm interferon raws li kev kho mob rau daim siab.Thaum Lub Ob Hlis 3, 2014, GlaxoSmithKline tshaj tawm tias FDA tau tso cai rau kev kho cov tshuaj kho mob uas tsim nyog ntawm Eltrombopag rau kev kho mob hemopenia hauv cov neeg mob uas muaj cov tshuaj lom neeg mob hnyav aplastic anemia (SAA) uas tsis tau teb tag nrho cov tshuaj tiv thaiv kab mob.Thaum Lub Yim Hli 24, 2015, US FDA tau pom zoo Eltrombopag rau kev kho mob thrombocytopenia hauv cov neeg laus thiab cov menyuam yaus hnub nyoog 1 xyoos thiab tshaj nrog cov kab mob tiv thaiv kab mob thrombocytopenia (ITP) uas tsis muaj cov lus teb tsis txaus rau corticosteroids, immunoglobulins lossis splenectomy.Thaum Lub Ib Hlis Ntuj Tim 4, 2018, Eltrombopag tau pom zoo kom muab teev rau hauv Suav teb rau kev kho mob thawj lub cev tiv thaiv kab mob thrombocytopenia (ITP).