2-butyl-5-nitro-3-benzofuranyl) [4-[3-(dibutylaMino)propoxy]phenyl]

Nws yog siv hauv kev kho mob hauv thawj thiab theem nrab Hyperuricemia, tshwj xeeb tshaj yog rau cov neeg mob hyperuricemia, nrog rau cov neeg mob lub raum tsis ua haujlwm, thiab cov neeg mob uas rov muaj dua lossis mob gout, nrog rau cov neeg mob hyperuricemia.Siv rau cov neeg mob Gouty nephropathy los txo cov tsos mob thiab txo qhov tsim ntawm lub raum uric acid pob zeb;pob zeb gout;siv nyob rau hauv uric acid raum pob zeb thiab uric acid raum kab mob.

Cov tshuaj tiv thaiv arrhythmic tshiab Atrial fibrillation (AF) yog ib yam kab mob uas ua rau muaj kev phom sij rau lub neej.Vim muaj kev laus ntawm cov pejxeem, qhov tshwm sim thoob ntiaj teb thiab kev tuag ntawm atrial fibrillation tau nce, thiab nws tau dhau los ua cov teeb meem kev noj qab haus huv tshiab.Muaj 2.5 lab tus neeg mob atrial fibrillation hauv Tebchaws Meskas thiab 4.5 lab hauv European Union.Raws li kev txheeb cais, qhov tshwm sim ntawm atrial fibrillation ntawm cov neeg muaj hnub nyoog tshaj 30 xyoo hauv kuv lub teb chaws yog 0.77%, uas nce nrog hnub nyoog, thiab txiv neej siab dua poj niam (0.9%: 0.7%).Cov kab mob uas ua rau atrial fibrillation feem ntau muaj xws li kub siab, kab mob plawv, kab mob valvular, spontaneous dilated cardiomyopathy, thiab lub plawv tsis ua hauj lwm.Cov tsos mob tseem ceeb ntawm cov neeg mob uas muaj atrial fibrillation yog qhov tsis xwm yeem ventricular npaum li cas, thiab kev tswj lub plawv dhia ua haujlwm nyob rau hauv qee txoj haujlwm hauv kev kho mob hnyav thiab kho cov tsos mob.Amiodarone plays lub luag haujlwm zoo hauv kev tswj lub plawv dhia thiab kho cov kab mob hauv lub qhov ntswg, tab sis qhov tsis zoo ntawm lub hom phiaj ntawm lub cev muaj feem xyuam nrog iodine tivthaiv hauv nws cov qauv txwv nws cov ntawv kho mob, xws li kev puas tsuaj rau lub ntsws, thyroid, thiab daim siab.Cov lus hais saum toj no-hais tsis zoo tshwm sim thiab nws cov qauv Lub iodine nyob rau hauv zoo sib xws.Cov tshuaj antiarrhythmic tshiab Dronedarone (Dronedarone) tau txais los ntawm kev hloov kho cov qauv ntawm amiodarone.Dronedarone muaj cov khoom siv hluav taws xob zoo ib yam li amiodarone, tab sis tsis muaj iodine hauv nws cov qauv, yog li nws tuaj yeem zam qhov kev mob tshwm sim hnyav ntxiv los ntawm iodine Chemicalbook.Dronedarone tau pom zoo rau kev lag luam los ntawm US Food and Drug Administration (FDA) thaum Lub Xya Hli 2009, thiab tau pom zoo rau kev lag luam hauv European Union hauv 2009. Nws kuj yog thawj cov tshuaj tiv thaiv kab mob tshiab tau pom zoo nyob hauv European Union hauv 10 xyoo.Dronedarone yog N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]phenyl]-5-benzofuranyl]-methanesulfonamide, uas yog los txo A benzofuran derivative tau los ntawm kev hloov kho cov qauv ntawm amiodarone, uas tsis yog ib tug plawv tsis zoo tshwm sim.Nws tshem tawm cov iodine atom hauv amiodarone kom txo tau cov tshuaj toxicity ntawm cov thyroid thiab lwm yam kabmob;Ntxiv ib pab pawg methylsulfonyl nyob rau sab benzofuran kom txo lipophilicity, yog li ua kom luv luv ntawm ib nrab-lub neej ntawm cov tshuaj thiab txo cov nyhuv ntawm cov ntaub so ntswg thiab muaj peev xwm ntawm cov tshuaj ntawm neurotoxicity.Ob lub 2011 US version thiab 2010 European version ntawm Atrial Fibrillation Guidelines pom zoo dronedarone rau kev kho mob ntawm atrial fibrillation.Dronedarone muaj kev nyab xeeb thiab siv tau zoo hauv kev kho mob ventricular npaum li cas thiab tswj qhov sinus hauv ntau tus neeg mob yam tsis muaj AF hnyav.Nws tuaj yeem yog ib qho tshuaj zoo los hloov amiodarone.Dronedarone tseem tuaj yeem txo qhov kev tuag ntawm cov neeg mob AF thiab txawm tias cov neeg mob AF tsis tu ncua.Yog li ntawd, nws yuav tsum yog thawj kab tshuaj rau cov neeg mob AF yam tsis muaj lub plawv tsis ua haujlwm hnyav.Ntxiv mus, kev siv cov tshuaj anticoagulants nyob rau hauv nruab nrab-high-risk AF cov neeg mob tau txais txiaj ntsig zoo rau kev siv dronedarone.