4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin;
4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin;
Nws ua haujlwm los ntawm stimulating central presynaptic alpha 2- receptors.Nws cov nyhuv hypotensive zoo ib yam li nifedipine, calcium antagonist, thiab captopril, ACE inhibitor.Rau qhov tseem ceeb kub siab.
Cov khoom no yuav tsum tau txais lub hauv paus ntsiab lus ntawm tus kheej cov tshuaj.Feem ntau pib los ntawm cov koob tshuaj qis tshaj plaws, uas yog, 0.2mg, ib hnub ib zaug, noj thaum sawv ntxov.Kev kho tshuaj yuav tsum tau ua nyob rau ntawm peb lub lis piam ib ntus kom txog thaum tau txais txiaj ntsig zoo.Qhov koob tshuaj ib txwm yog 0.2mg ib zaug, ob zaug ib hnub (sab sawv ntxov thiab yav tsaus ntuj).Qhov siab tshaj plaws koob tshuaj ib zaug yuav tsum tsis pub tshaj 0.4mg, thiab qhov siab tshaj plaws koob tshuaj txhua hnub yuav tsum tsis txhob ntau tshaj 0.6mg.Rau cov neeg mob uas mob me lossis mob raum tsis txaus, ib koob tshuaj yuav tsum tsis pub tshaj 0.2 mg lossis ib hnub koob tshuaj yuav tsum tsis pub tshaj 0.4 mg.
Cov khoom no yog ib qho α2-receptor agonist, uas yog imidazoline antihypertensive tshuaj.Siv rau nruab nrab thiab hnyav thawj thiab theem nrab kub siab.
Vim nws inhibits secretion thiab txav ntawm lub plab hnyuv ib ntsuj av, nws kuj yog haum rau cov neeg mob hypertensive kev txom nyem los ntawm ulcers.Kev sib xyaw ntawm cov tshuaj no thiab cov tshuaj diuretics tuaj yeem txhim kho kev ua tau zoo.Nws yog cov tshuaj muaj zog hauv nruab nrab cov tshuaj tiv thaiv hypertensive thiab cov tshuaj thib ob-kab antihypertensive.Nws yog tsuas yog tswj hwm hauv zos hauv ophthalmology.Cov khoom no muaj cov nyhuv ntawm kev txo qis intraocular siab, thiab tsis cuam tshuam rau cov menyuam kawm ntawv thiab lub qhov muag kho mechanism.Nws tuaj yeem cuam tshuam cov hlab ntsha hauv lub qhov muag, txo cov khoom ntawm aqueous lom zem, thiab ua tiav cov txiaj ntsig ntawm kev txo qis intraocular siab.Nws pib siv 15 feeb tom qab qhov muag tee thiab tuaj yeem tswj cov nyhuv li ntawm 8 teev.
Txheem:EP 10
Cov ntsiab lus ntsuam xyuas:97.5-102.0%
Sab nrauv:Dawb los yog yuav luag thaum hmoov
Pob:1kg / hnab lossis raws li cov neeg siv khoom xav tau
JIN DUN Medical muajISO tsim nyog thiab ua tau raws li GMP cov qauv tsim, ua hauj lwm hauv tsev thiab txawv teb chaws cov kws kho tshuaj synthesis nrog kev nplua nuj los coj lub tuam txhab R & D.
TECHNOL OGY ADVANTAGES
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction.Cryogenic cov tshuaj tiv thaiv (<-78% C)
●Aromatic Heterocyclic Synthesis
● Kev Ruaj Ntseg Tsis Zoo
● Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Gignard Reaction
Cov khoom siv
Peb lub Lab muaj ntau yam kev sim thiab ntsuas cov cuab yeej, xws li: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope ...
Pab neeg R&D
Jindun Kev Kho Mob muaj ib pab pawg kws tshaj lij R & D cov neeg ua haujlwm, thiab ntiav ntau tus kws tshaj lij kev siv tshuaj hauv tsev thiab txawv teb chaws los coj R&D, ua rau peb cov khoom sib xyaw ua kom raug thiab ua tau zoo.
Peb tau pab ntau lub tuam txhab tshuaj hauv tsev sab saum toj, xws liHansoh, Hengrui thiab HEC Pharm.Ntawm no peb yuav qhia ib feem ntawm lawv.
Customzation Case Ib:
CAS Nr .: 110351-94-5
Customzation Case Ob:
CAS Nr .: 144848-24-8
Customzation Case Peb:
CAS Nr .: 200636-54-0
1.Customize New Intermediates lossis APIs.Ib yam li cov ntaub ntawv sib qhia saum toj no, cov neeg siv khoom muaj qhov xav tau tshwj xeeb Intermediates lossis APIs, thiab lawv nrhiav tsis tau cov khoom xav tau hauv khw, ces peb tuaj yeem pab kho.
2.Txheej txheem Optimization rau cov khoom qub.Peb pab neeg yuav pab Optimize thiab txhim kho xws li ntau lawm uas nws cov tshuaj tiv thaiv txoj kev yog qub, ntau lawm nqi yog siab, thiab efficiency yog tsawg.Peb tuaj yeem muab cov ntaub ntawv tag nrho rau kev hloov pauv thev naus laus zis thiab kev txhim kho cov txheej txheem, pab cov neeg siv khoom kom muaj txiaj ntsig ntau dua.
Los ntawm cov hom phiaj tshuaj rau INDs, JIN DUN Kev Kho Mob muab rau kojib-nres tus kheej R & D kev daws teeb meem.
JIN DUN Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom muaj txiaj ntsig, ua kom zoo, nruj, thiab tawm mus ua ib tus neeg ntseeg siab thiab phooj ywg ntawm cov neeg siv khoom!
