Casp ungin Acetate; Caspofungin acetate; Cancidas; Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate; Caspofungin acetate; Cancidas; Caspofungin acetate [USAN:BAN:JAN];Cov duab tshwj xeeb](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate; Caspofungin acetate; Cancidas; Caspofungin acetate [USAN:BAN:JAN];
Caspofungin Acetate Biological Kev Ua Haujlwm
| Piav | Caspofungin Acetate yog ib qho tshuaj tiv thaiv kab mob uas tuaj yeem ua rau tsis muaj kev sib tw inhibit qhov kev sib txuas ntawm 1,3-β-d glucan synthase. |
| Hais txogpawg | teeb liab txoj kev >> Anti-kis >> Fungus Tshawb xyuas thaj chaw >> Kab mob |
| Hauv vivokev tshawb fawb | Cov nas txhaj nrog caspofungin tsis muaj qhov hloov pauv tseem ceeb hauv lawv cov ERG waveform ntawm vitreous concentration ntawm 0.41 txog 4.1 μM, thiab lawv cov retina tsis muaj kev hloov pauv morphological lossis cell poob.Ntawm qhov vitreous concentration ntawm 41 μM, caspofungin txo qhov amplitude ntawm lub nthwv dej, b nthwv dej thiab scotopic pib teb ntawm ERG, thiab kuj ua rau txo qis ntawm cov cell hauv ganglion cell txheej [1].Carprofungin (8 mg / kg) lossis amphotericin B 1 mg / kg, txhaj tshuaj intraperitoneal ib hnub ib zaug 30 teev tom qab kis kab mob rau 7 hnub sib law liag, txheeb ze rau kev tswj xyuas tsheb, 100% ciaj sia nyob rau hnub 28, ua rau nruab hnub 100% kev tuag 11 , tom qab kis kab mob sib tw.Piv nrog rau kev tswj hwm lub tsheb nyob rau hnub 5, caspofungin txo qhov kev rov qab los ntawm Candida hauv lub raum thiab lub paj hlwb thaum lub zog tswj tau mus txog qhov kawg.Cov nas kho nrog caspofungin ntawm koob tshuaj 2 mg / kg lossis siab dua tau txo qis hauv lub hlwb nyob rau hnub 5 dua li nas kho nrog amphotericin B. Amphotericin B thiab caspofungin kev kho mob txo lub raum kab mob los ntawm 1.7 log CFU / g thiab 2.46 txog 3.64 teev CFU. /g, raws li [2]. |
| Tsiajkev sim | Kev kho tshuaj tua kab mob tau pib 30 teev tom qab kev sib tw kis kab mob thiab tau muab los ntawm kev txhaj tshuaj intraperitoneal (ip) ib hnub ib zaug rau 7 hnub.Cov nas raug kho nrog 1, 2, 4, lossis 8 mg / kg / hnub caspofungin, 1 mg / kg / hnub amphotericin B lossis kev tswj tsheb (cov dej tsis huv).Kev ua tau zoo ntawm tus qauv tau soj ntsuam nyob rau hauv peb txoj kev: los ntawm kev saib xyuas cov ciaj sia taus ntawm 10 tus tsiaj hauv txhua pab pawg kho mob, los ntawm kev saib xyuas Candida load nyob rau hauv lub raum thiab lub hlwb cov ntaub so ntswg ntawm ob pawg tsiaj kho, thiab los ntawm histologically ntsuam xyuas lub raum.Thiab lub hlwb.Pab pawg thib peb ntawm cov tsiaj kho.Cov nas tau euthanized los ntawm CO 2 inhalation thiab kab lis kev cai ntawm 30 teev (tsuas yog kev kho tsheb thauj khoom) thiab hnub 5 (24 teev tom qab koob thib 4), 8 (24 teev tom qab koob tshuaj zaum kawg), thiab 14, 21 teev thiab histological cov ntaub so ntswg sampling.(Tsuas yog kev kho mob caspofungin), thiab 28 tom qab kev tawm tsam. |
| Cov ntaub ntawv | [1].Mojumder DK, et al.Kev ntsuam xyuas cov tshuaj toxicity ntawm cov tshuaj intravitreal caspofungin hauv lub qhov muag nas.Invest Ophthalmol Vis Sci.2010 Nov; 51(11):5796-803. [2].Flattery, Amy M. et al.Kev ua tau zoo ntawm caspofungin nyob rau hauv ib tug me nyuam mos qauv ntawm central paj hlwb candidiasis.Antimicrobial Agents and Chemotherapy (2011), 55(7), 3491-3497. |
Cov khoom siv tshuaj thiab lub cev ntawm caspofungin acetate
| Boiling point | 1408.1ºC ntawm 760 mmHg |
| Cov mis mos molecular | C56H96N10O19 |
| Molecular hnyav | 1093.31000 Nws |
| Precise zoo | 1092.64000 Nws |
| PSA | 412.0300 Nws |
| LogP | 0.0615 0 |
| Cov tsos mob tshwm sim | dawb rau beige |
| Vapor siab | 0 mmHg ntawm 25 ° C |
| Cia tej yam kev mob | 20 ° C |
| Dej solubility | H2O: soluble 15mg / mL (ntshiab kua) |
Caspofungin Acetate Kev lis kev cai
| Kev lis kev cai code | 293390099 ib |
| Suav Txheej txheem cej luam | 2933990099. Lwm cov tshuaj heterocyclic uas muaj nitrogen heteroatoms xwb.Tus nqi se ntxiv: 17.0%.Tus nqi se rov qab: 13.0%.Regulatory tej yam kev mob: Tsis muaj.Feem ntau cov neeg nyiam tariff: 6.5%.Tus nqi se: 20.0% |
| Cov ntsiab lus tshaj tawm | Cov khoom npe, cov ntsiab lus muaj, siv, hexamethylene chloride, thov qhia qhov tsos, 6-caprolactam, thov qhia qhov tsos, kos npe hnub |
| Cov ntsiab lus | 2933990090. heterocyclic compounds nrog nitrogen hetero-atom(s) nkaus xwb.VAT: 17.0%.Tus nqi se rov qab: 13.0%..MFN tariff: 6.5%.Tus nqi se: 20.0% |
Txheej txheem ntau lawm
Caspofungin yuav tsum tau npaj los ntawm fermentation semi-synthetic technology.Cov khoom nyoos ntawm lub nplhaib tseem ceeb yuav tsum tau txais los ntawm kev siv tshuab fermentation, thiab tom qab ntawd cov khoom nruab nrab tau txais los ntawm kev sib cais thiab kev ua kom huv, thiab tom qab ntawd cov khoom nruab nrab yog siv los ua cov khoom pib los ua kom tiav cov saw hlau sib txuas siv cov cuab yeej siv hluavtaws kom tau txais cov khoom siv nruab nrab. lub hom phiaj Element.Vim hais tias cov khoom "fermented semi-synthetic" yuav tsum tau mus los ntawm ntau yam kev sib txuas xws li fermentation, sib cais thiab purification, synthesis, thiab lwm yam., txoj kev technical thiab txheej txheem parameter tswj yog heev nyuaj nyob rau hauv Chemicalbook.Tsis tas li ntawd, cov kev cai tswjfwm rau kev sau npe ntawm caspofungin, cov khoom fermented semi-synthetic, kuj yog siab heev.Daim ntawv thov cov ntaub ntawv yuav tsum pib los ntawm qhov chaw fermentation, tsis yog tsuas yog mus rau systematically kawm strain cultivation, fermentation technology, thiab purification technology, tab sis kuj mus tshawb cov txheej txheem synthesis.Txoj kev, tej yam kev mob, thiab kev tswj ntawm impurities nyob rau hauv tus txheej txheem, vim hais tias cov khoom zaum kawg yog ib qho yooj yim heev, ib qho kev tsis txaus siab yuav so tawm tag nrho cov kev siv zog yav dhau los, thiab cov kev nyuaj thiab cov nqi tsis tseem ceeb.
Nws yog qhov tseeb vim tias muaj kev cuam tshuam kev lag luam siab thiab thaj chaw zoo sib tw uas Hengrui Caspofungin tau tuav tus nqi zoo tom qab nws cov npe.
Patent kev tiv thaiv tas sij hawm nyob rau hauv 2014
Kev muag khoom ntawm lub davhlau ya nyob twg caspofungin txhaj tshuaj hauv cov tsev kho mob pej xeem hauv Suav teb (unit: kaum txhiab yuan)
Txog tam sim no, tsuas yog cov tshuaj nquag ntawm Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, thiab Haisco tau pom zoo rau npe.Huadong tshuaj?
Thawj lub tuam txhab tshawb fawb ntawm caspofungin acetate yog Merck, thiab daim ntawv teev npe ntawm 6 lub tuam txhab raug tshuaj xyuas thiab pom zoo, uas yog Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, thiab Tian Weisex.
JIN DUN Medical muajISO tsim nyog thiab ua tau raws li GMP cov qauv tsim, ua hauj lwm hauv tsev thiab txawv teb chaws cov kws kho tshuaj synthesis nrog kev nplua nuj los coj lub tuam txhab R & D.
TECHNOL OGY ADVANTAGES
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction.Cryogenic cov tshuaj tiv thaiv (<-78% C)
●Aromatic Heterocyclic Synthesis
● Kev Ruaj Ntseg Tsis Zoo
● Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Gignard Reaction
Cov khoom siv
Peb lub Lab muaj ntau yam kev sim thiab ntsuas cov cuab yeej, xws li: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope ...
Pab neeg R&D
Jindun Kev Kho Mob muaj ib pab pawg kws tshaj lij R & D cov neeg ua haujlwm, thiab ntiav ntau tus kws tshaj lij kev siv tshuaj hauv tsev thiab txawv teb chaws los coj R&D, ua rau peb cov khoom sib xyaw ua kom raug thiab ua tau zoo.
Peb tau pab ntau lub tuam txhab tshuaj hauv tsev sab saum toj, xws liHansoh, Hengrui thiab HEC Pharm.Ntawm no peb yuav qhia ib feem ntawm lawv.
Customzation Case Ib:
CAS Nr .: 110351-94-5
Customzation Case Ob:
CAS Nr .: 144848-24-8
Customzation Case Peb:
CAS Nr .: 200636-54-0
1.Customize New Intermediates lossis APIs.Ib yam li cov ntaub ntawv sib qhia saum toj no, cov neeg siv khoom muaj qhov xav tau tshwj xeeb Intermediates lossis APIs, thiab lawv nrhiav tsis tau cov khoom xav tau hauv khw, ces peb tuaj yeem pab kho.
2.Txheej txheem Optimization rau cov khoom qub.Peb pab neeg yuav pab Optimize thiab txhim kho xws li ntau lawm uas nws cov tshuaj tiv thaiv txoj kev yog qub, ntau lawm nqi yog siab, thiab efficiency yog tsawg.Peb tuaj yeem muab cov ntaub ntawv tag nrho rau kev hloov pauv thev naus laus zis thiab kev txhim kho cov txheej txheem, pab cov neeg siv khoom kom muaj txiaj ntsig ntau dua.
Los ntawm cov hom phiaj tshuaj rau INDs, JIN DUN Kev Kho Mob muab rau kojib-nres tus kheej R & D kev daws teeb meem.
JIN DUN Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom muaj txiaj ntsig, ua kom zoo, nruj, thiab tawm mus ua ib tus neeg ntseeg siab thiab phooj ywg ntawm cov neeg siv khoom!
