Guanosine

Guanosine yog siv los ua qhov nruab nrab ntawm Valaciclovir.
Valacyclovir yog guanine analogue tshuaj tua kab mob.Nws yog siv nyob rau hauv kev kho mob ntawm herpes simplex thiab herpes zoster kab mob nyob rau hauv kev sib deev kab mob.Cov khoom no yog qhov ua ntej ntawm acyclovir.Nws tau nqus sai sai tom qab kev tswj hwm qhov ncauj thiab hloov mus rau acyclovir hauv lub cev sai.Nws cov nyhuv antiviral yog ua si los ntawm acyclovir.Tom qab acyclovir nkag mus rau hauv cov kab mob herpes, nws sib tw nrog deoxynucleoside rau tus kab mob thymidine deoxynucleoside kinase los yog cell kinase, thiab cov tshuaj yog phosphorylated rau hauv activated acyclic guanosine triphosphate.Raws li lub substrate ntawm tus kab mob replication, acyclovir sib tw nrog deoxyguanine triphosphate rau tus kab mob DNA polymerase, uas inhibits tus kab mob DNA synthesis thiab qhia antiviral nyhuv.Cov tshuaj tiv thaiv kab mob ntawm cov khoom no hauv vivo yog qhov zoo dua li acyclovir, thiab kev kho mob ntawm tus kab mob herpes simplex hom I thiab hom II yog 42.91% thiab 30.13% siab dua acyclovir feem.Nws kuj tseem muaj kev kho mob siab rau tus kab mob varicella zoster.