Lub lim tiam no, cov ntawv xov xwm zoo tshaj plaws tau luam tawm cov ntawv tshawb fawb online los ntawm xibfwb Feng Liang pab pawg ntawm Stanford University, qhia txog cov qauv thiab kev ua haujlwm ntawm cov ntshav-hlwb barrier lipid thauj protein MFSD2A.Qhov kev tshawb pom no pab tsim cov tshuaj los tswj cov permeability ntawm cov ntshav-hlwb barrier.
MFSD2A yog phospholipid transporter uas yog lub luag haujlwm rau kev nce ntawm docosahexaenoic acid mus rau hauv lub hlwb hauv cov hlwb endothelial uas ua rau cov ntshav-hlwb barrier.Docosahexaenoic acid yog zoo dua lub npe hu ua DHA, uas yog ib qho tseem ceeb rau kev loj hlob thiab kev ua tau zoo ntawm lub hlwb.Kev hloov pauv uas cuam tshuam rau kev ua haujlwm ntawm MFSD2A tuaj yeem ua rau muaj teeb meem kev loj hlob hu ua microcephaly syndrome.
Lub peev xwm thauj lipid ntawm MFSD2A kuj txhais tau tias cov protein no muaj feem cuam tshuam nrog kev ncaj ncees ntawm cov hlab ntsha-hlwb barrier.Cov kev tshawb fawb yav dhau los tau pom tias thaum nws qhov kev ua haujlwm txo qis, cov ntshav-hlwb barrier yuav xau.Yog li ntawd, MFSD2A yog suav tias yog ib qho kev cog lus hloov pauv thaum nws tsim nyog los hla cov ntshav-hlwb thaiv kom xa cov tshuaj kho mob mus rau hauv lub hlwb.
Nyob rau hauv txoj kev tshawb no, xib fwb Feng Liang pab neeg siv cryo-electron microscopy thev naus laus zis kom tau txais cov qauv kev daws teeb meem ntawm nas MFSD2A, nthuav tawm nws qhov tshwj xeeb extracellular domain thiab substrate binding kab noj hniav.
Kev sib xyaw ua haujlwm thiab kev sim ua kom muaj zog molecular, cov kws tshawb fawb kuj tau txheeb xyuas qhov chaw khaws cia sodium binding qhov chaw hauv cov qauv ntawm MFSD2A, nthuav tawm txoj hauv kev muaj peev xwm lipid nkag, thiab pab kom nkag siab tias yog vim li cas MFSD2A kev hloov pauv ua rau microcephaly syndrome.
Post lub sij hawm: Sep-01-2021