1.Shanghai tau tshaj tawm cov tshuaj suav tshuaj patent thiab kev npaj yooj yim thiab tsis siv tshuaj kho mob los pab tib neeg tiv thaiv kab mob khaub thuas caij nplooj ntoos hlav.
Shanghai Municipal Administration of Traditional Chinese Medicine tau tshaj tawm rau hnub tim 5 tias National Base for the Prevention and Control of Chinese Medicine Epidemic Diseases (Shanghai) tau ua tus thawj coj hauv kev tsim kho Suav Tshuaj Tiv Thaiv thiab Tswj Kev Npaj rau Xyoo 2023 Caij Nplooj Ntoos Hlav hauv Shanghai (Tsim) (tom qab no hu ua txoj kev npaj), tau npaj kev nkag siab ntawm Suav tshuaj ntawm tus mob khaub thuas, tsim cov tshuaj suav tshuaj rau cov neeg laus thiab cov menyuam yaus raws li kev sib txawv ntawm cov kab mob, thiab tau tsim ntau yam tshuaj suav tshuaj patent thiab kev npaj yooj yim thiab tsis siv tshuaj kho mob rau kev tiv thaiv kab mob khaub thuas thiab tswj. .
Nyob rau lub caij ntuj no thiab caij nplooj ntoos hlav, huab cua sov thiab txias, qhov kub thiab txias sib txawv ntawm nruab hnub thiab hmo ntuj yog qhov hloov pauv, thiab cov kab mob sib kis raws caij nyoog tau nkag mus rau qhov xwm txheej siab thiab lub sijhawm sib kis.Tsis ntev los no, tus naj npawb ntawm cov neeg mob khaub thuas A thiab lwm yam kab mob tau txais los ntawm cov tsev kho mob loj hauv Shanghai tau nce ntxiv.Lub hom phiaj yog txhawm rau muab kev ua si tag nrho rau cov yam ntxwv thiab qhov zoo ntawm cov tshuaj suav tshuaj hauv kev tiv thaiv thiab kho mob khaub thuas.
Zhang Wei, ib tus kws sau ntawv ntawm txoj kev npaj, tus thawj coj ntawm pab pawg kws tshaj lij ntawm COVID-19 rau Kev Kho Mob Suav Tshuaj Kho Mob thiab tus thawj coj ntawm Lub Tsev Haujlwm Saib Xyuas Kab Mob Pulmonary ntawm Shuguang Tsev Kho Mob, ntseeg hais tias kev txhim kho tus mob khaub thuas (fluenza) feem ntau yog tus kheej. txwv.Qee cov menyuam yaus tsis muaj zog thiab cov neeg laus muaj cov kab mob hauv qab tuaj yeem ua rau lwm yam teeb meem vim yog cov kab mob exogenous, uas yog lub hom phiaj ntawm kev tiv thaiv thiab kev kho mob ntawm cov tshuaj suav tshuaj thiab cov tshuaj sab hnub poob.Nws hais rau cov neeg sau xov xwm tias cov tshuaj suav tshuaj suav hais tias tus mob khaub thuas yog nyob rau hauv qeb mob khaub thuas tam sim no.Raws li kev nkag siab ib txwm muaj, kev kuaj mob thiab kev kho mob feem ntau yog raws li kev sib txawv ntawm cov kab mob sib txawv thiab kev kho mob ntawm 6 meridians, kev sib txawv ntawm Weiqi thiab Yingxue, thiab cov kab mob sib txawv thiab kev kho mob ntawm peb jiao, thiab kev saib xyuas. yog them rau kev sib xyaw ua ke ntawm kev ntxiv dag zog thiab tshem tawm cov kab mob pathogenic los ntawm theem thiab theem.
"Tus kab mob khaub thuas feem ntau yog txwv tsis pub tus kheej thiab tuaj yeem kho tau hauv lub sijhawm luv luv tom qab kev kho cov tsos mob thiab kev cuam tshuam TCM."Zhang Wei tau taw qhia tias, ntxiv rau cov tshuaj suav tshuaj patent thiab cov kev npaj yooj yim tau pom zoo hauv cov tswv yim, TCM cov tsev kho mob loj hauv Shanghai muaj kev paub ntau yam hauv kev kuaj mob thiab kev kho mob khaub thuas, nrog rau cov kev npaj hauv tsev kho mob thiab tshuaj noj.
Nws tau tshaj tawm tias qhov kis tsis ntev los no feem ntau yog H1N1.Piv nrog rau tus mob khaub thuas, nws kis tau zoo heev, kub taub hau thiab kav ntev dua, muaj cov tsos mob pom tseeb dua, thiab muaj kab mob ntev dua.
Xue Zheng, tus kws sau ntawv Cov Kev Pabcuam Menyuam Yaus thiab tus thawj coj ntawm Lub Tsev Haujlwm Saib Xyuas Menyuam Yaus ntawm Shanghai Municipal Hospital of Traditional Chinese Medicine, ntseeg tias cov menyuam yaus hnub nyoog qis dua 5 xyoos yuav raug mob khaub thuas.Cov menyuam yaus raug mob khaub thuas thiab muaj cov tsos mob hnyav vim lawv lub ntsws tsis zoo.Cov tshuaj suav tshuaj suav ua lub luag haujlwm zoo heev hauv kev tiv thaiv thiab kho tus mob khaub thuas hauv cov menyuam yaus, tshwj xeeb tshaj yog hauv kev kho mob khaub thuas A, uas tuaj yeem cuam tshuam kev sib kis thiab qhov tob ntawm tus kab mob, txhim kho cov tsos mob sai, thiab muaj qhov dav dav.Pediatrics hauv cov tsev kho mob loj hauv Suav thiab Western kuj tseem muaj cov kev npaj hauv tsev kho mob loj uas tau siv dav hauv kev kho mob.
Txoj kev npaj tau tsim daim ntawv cog lus tshuaj suav tshuaj suav tshuaj thiab tshuaj suav tshuaj suav tshuaj patent thiab kev npaj yooj yim rau kev kho mob khaub thuas me nyuam yaus, thiab tseem tau npaj cov txheej txheem kev kho mob sab nraud yooj yim thiab pheej yig ntawm cov tshuaj suav tshuaj.Cov niam txiv tuaj yeem ua cov tshuaj suav tshuaj hauv Suav teb los ntawm kev kho mob sab nraud xws li kev noj zaub mov, zaws, pob ntseg, daim ntawv thov thiab tshuaj tsw qab pendant kho los pab cov menyuam yaus txhim kho cov tsos mob sai thiab rov zoo sai li sai tau.
2.Cov kws tshawb fawb tshawb fawb pom muaj cov tshuaj tiv thaiv kab mob siab hepatoma los ntawm cov nroj tsuag tshuaj Artemisia annua.
Lub koom haum Kunming ntawm Botany, Suav Academy ntawm Sciences, tshaj tawm rau hnub tim 21 tias Chen Jijun cov kev tshawb fawb pab neeg tau pom ib tug series ntawm tshiab sesquiterpene dimers nrog los tiv thaiv daim siab mob cancer ua los ntawm cov tshuaj cog Artemisia scoparia.Cov txiaj ntsig kev tshawb fawb ntsig txog tsis ntev los no tau luam tawm nyob rau hauv phau ntawv xov xwm nto moo thoob ntiaj teb Kev Tshaj Tawm Tshaj Tawm thiab Kev Kho Mob.
Mob qog noj ntshav yog ib hom qog nqaij hlav uas ua rau tib neeg noj qab haus huv.Txhua xyoo, tus naj npawb ntawm cov neeg mob tshiab ntawm daim siab mob qog noj ntshav hauv ntiaj teb tau tshaj 840000, thiab cov neeg tuag los ntawm mob qog noj ntshav nce mus txog 780000, thaum txog 50% ntawm cov neeg mob tshiab tshwm sim hauv Suav teb.Tam sim no, muaj plaub tyrosine kinase inhibitors, sorafenib, regafinil, lovatinib thiab cabotinib, ib vascular endothelial kev loj hlob yam receptor 2 antagonist, ramolumab, thiab ob PD-1 inhibitors, navumab thiab pamuzumab, uas yog siv nyob rau hauv kev kho mob ntawm daim siab mob cancer. , tab sis hom qauv yog qhov yooj yim thiab yooj yim los tsim cov tshuaj tiv thaiv.
Nyob rau hauv xyoo tas los no, Chen Jijun cov kev tshawb fawb pab pawg tau cog lus los tshawb nrhiav cov tshuaj tiv thaiv kab mob siab hepatoma thiab cov tshuaj tshiab nrog cov qauv tshwj xeeb thiab cov txheej txheem tshiab ntawm kev txiav txim los ntawm cov nroj tsuag Artemisia, thiab tau ua tiav txoj kev sib cais los ntawm kev sib koom ua ke ntawm kev lees paub ntawm sesquiterpene dimers hauv Artemisia. cov nroj tsuag nrog kev taug qab ntawm kev tiv thaiv kab mob hepatoma.Txoj kev tshawb no pom thawj zaug uas cov extract ntawm Artemisia annua muaj zog inhibitory kev ua si ntawm peb hepatoma hlwb, thiab thawj zaug, 36 tshiab sesquiterpene dimers ntawm 9 yam qauv - Artemisia annua A1-A3, B1-B2, C1-C4 , D, E, F1-F15, G1-G8, H thiab kuv tau raug cais tawm ntawm qhov chaw nquag ntawm Artemisia annua.
Cov kev tshawb fawb ntxiv tau pom tias ntawm 36 tshiab sesquiterpene dimers, cov haujlwm ntawm artemisinin G5 thiab G7 yog qhov zoo tshaj plaws, uas yog sib npaug rau thawj kab tshuaj tiv thaiv kab mob siab hepatoma tshuaj sorafenib;Tsis tas li ntawd, yav qab teb artemisinin G7 pom zoo xaiv thiab kev nyab xeeb dua li sorafenib rau THLE-2 nyob rau hauv ib txwm lub siab hlwb;Nyob rau tib lub sijhawm, artemisinin G7 yav qab teb tuaj yeem cuam tshuam kev loj hlob ntawm HepG2 hlwb los ntawm inhibiting kev ntxeem tau thiab tsiv teb tsaws ntawm hepatoma hlwb, inducing apoptosis thiab thaiv G2 / M cell voj voog.
Txoj kev tshawb no tau nthuav tawm thawj zaug ntawm cov sesquiterpene dimers nrog cov pob txha tshiab thiab cov qauv sib txawv hauv Artemisia annua, txhawb nqa cov txheej txheem ntawm sesquiterpene dimers hauv cov nroj tsuag Artemisia, thiab muab ntau yam ntawm cov neeg sib tw molecules thiab lub hauv paus tseem ceeb rau kev tshawb fawb ntawm cov tshuaj tiv thaiv tshiab. - tshuaj hepatoma.
Txog niaj hnub no, Chen Jijun cov kev tshawb fawb pab pawg tau cais thiab txheeb xyuas 122 tshiab sesquiterpenoid dimers nrog kev tiv thaiv kab mob hepatoma los ntawm Artemisia australis, Artemisia sinica, Artemisia medinalis, Artemisia cowtail thiab Artemisia mongolica, suav txog 52% ntawm tag nrho cov naj npawb ntawm penoids qhia los ntawm 23. Artemisia nroj tsuag nyob rau hauv lub ntiaj teb no.
JinDun Kev Kho Mobmuaj kev tshawb fawb txog kev tshawb fawb mus sij hawm ntev thiab kev siv thev naus laus zis grafting nrog Suav tsev kawm qib siab.Nrog Jiangsu cov kev pab kho mob nplua nuj, nws muaj kev sib raug zoo ua lag luam mus sij hawm ntev nrog Is Nrias teb, Southeast Asia, Kaus Lim Qab Teb, Nyiv thiab lwm lub khw.Nws tseem muab kev lag luam thiab kev muag khoom hauv tag nrho cov txheej txheem los ntawm nruab nrab mus rau cov khoom tiav API.Siv cov peev txheej tsim nyog ntawm Yangshi Chemical hauv fluorine chemistry los muab kev pabcuam tshuaj tshwj xeeb rau cov neeg koom tes.Muab cov txheej txheem innovation thiab kev tshawb fawb impurity rau cov neeg siv khoom.
JinDun Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom lag luam muaj meej mom, nruj, nruj, thiab tawm mus ua tus neeg ntseeg siab thiab cov phooj ywg ntawm cov neeg siv khoom!One nres cov chaw muab kev pabcuam, kho R & D thiab kev pabcuam tsim khoom rau cov kws kho mob nruab nrab thiab APIs, kev tshaj lijcustomized tshuaj ntau lawm(CMO) thiab customized kws tshuaj R & D thiab ntau lawm (CDMO) muab kev pab cuam.
Post lub sij hawm: Mar-30-2023