(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3
Linagliptin Linagliptin, tsim los ntawm Boehringer Ingelheim, tau pom zoo los ntawm FDA thaum lub Tsib Hlis 2, 2011. Nws yog siv los ua ke kev noj haus thiab kev tawm dag zog los txhim kho kev tswj cov ntshav qabzib hauv cov neeg mob ntshav qab zib hom 2.Linagliptin txhim kho kev tswj ntshav qabzib hauv cov neeg mob los ntawm inhibiting dipeptidyl peptidase-4 (DPP-4).
Incretin (Incretin) muaj txiaj ntsig los txhawb kev tso tawm ntawm insulin los ntawm pancreatic islet B hlwb, feem ntau suav nrog cov piam thaj-dependent insulinotropic polypeptide (GIP) thiab glucagon-zoo li polypeptide-1 (GLP-1).DDP-4 yog ib qho serine protease nyob rau saum npoo ntawm cov hlwb.Nws khi rau cov proteins thiab muaj dav hauv cov ntshav thiab ntau cov ntaub so ntswg hauv lub cev (xws li lub raum, lub siab, lub plab hnyuv me, cov hlwb endothelial, thiab lwm yam).Linagliptin yog ib qho kev xaiv DPP-4 inhibitor uas inhibits kev ua haujlwm ntawm cov enzyme los ntawm reversibly khi rau DPP-4, ncua kev degradation ntawm GLP-1, txhim kho kev ua haujlwm ntawm GLP-1, thiab txhawb kev ua haujlwm ntawm cov piam thaj hauv insulin secretes thiab txo cov qib ntawm glucagon hauv cov hlab ntsha, yog li tswj cov ntshav qabzib hauv cov neeg mob ntshav qab zib hom 2.
Piv nrog rau lwm yam DPP-4 inhibitors, cov txiaj ntsig tseem ceeb ntawm Linagliptin yog: nws muaj lub raum kev nyab xeeb thiab tuaj yeem txo glycosylated hemoglobin zoo.Linagliptin feem ntau yog tawm hauv cov quav hauv daim ntawv qauv.Tom qab kev tswj hwm qhov ncauj, lub raum tso tawm tsuas yog 5% ntawm tus nqi tswj hwm.Txawm hais tias nws tau txhaj tshuaj intravenously, tsuas yog 30.8% tawm ntawm lub raum.Yog li ntawd, tsis muaj kev xav tau rau cov neeg mob uas tab tom kho.Tsis tu ncua xyuas daim siab thiab lub raum kev ua haujlwm thiab hloov koob tshuaj.Txhua tus neeg mob tuaj yeem kho qhov koob tshuaj kom zoo ib yam rau kev sau ntawv yooj yim.
Cov kev phiv tshwm sim ntawm Linagliptin yog kab mob ua pa, qhov ntswg congestion, mob nqaij, mob taub hau thiab mob caj pas.
Executive standard:tus qauv kev lag luam
Kev ntsuam xyuas:98-102%
Sab nrauv:Dawb mus rau yellowish crystalline hmoov
Pob:25kg / nruas
JIN DUN Medical muajISO tsim nyog thiab ua tau raws li GMP cov qauv tsim, ua hauj lwm hauv tsev thiab txawv teb chaws cov kws kho tshuaj synthesis nrog kev nplua nuj los coj lub tuam txhab R & D.
TECHNOL OGY ADVANTAGES
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction.Cryogenic cov tshuaj tiv thaiv (<-78% C)
●Aromatic Heterocyclic Synthesis
● Kev Ruaj Ntseg Tsis Zoo
● Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Gignard Reaction
Cov khoom siv
Peb lub Lab muaj ntau yam kev sim thiab ntsuas cov cuab yeej, xws li: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope ...
Pab neeg R&D
Jindun Kev Kho Mob muaj ib pab pawg kws tshaj lij R & D cov neeg ua haujlwm, thiab ntiav ntau tus kws tshaj lij kev siv tshuaj hauv tsev thiab txawv teb chaws los coj R&D, ua rau peb cov khoom sib xyaw ua kom raug thiab ua tau zoo.
Peb tau pab ntau lub tuam txhab tshuaj hauv tsev sab saum toj, xws liHansoh, Hengrui thiab HEC Pharm.Ntawm no peb yuav qhia ib feem ntawm lawv.
Customzation Case Ib:
CAS Nr .: 110351-94-5
Customzation Case Ob:
CAS Nr .: 144848-24-8
Customzation Case Peb:
CAS Nr .: 200636-54-0
1.Customize New Intermediates lossis APIs.Ib yam li cov ntaub ntawv sib qhia saum toj no, cov neeg siv khoom muaj qhov xav tau tshwj xeeb Intermediates lossis APIs, thiab lawv nrhiav tsis tau cov khoom xav tau hauv khw, ces peb tuaj yeem pab kho.
2.Txheej txheem Optimization rau cov khoom qub.Peb pab neeg yuav pab Optimize thiab txhim kho xws li ntau lawm uas nws cov tshuaj tiv thaiv txoj kev yog qub, ntau lawm nqi yog siab, thiab efficiency yog tsawg.Peb tuaj yeem muab cov ntaub ntawv tag nrho rau kev hloov pauv thev naus laus zis thiab kev txhim kho cov txheej txheem, pab cov neeg siv khoom kom muaj txiaj ntsig ntau dua.
Los ntawm cov hom phiaj tshuaj rau INDs, JIN DUN Kev Kho Mob muab rau kojib-nres tus kheej R & D kev daws teeb meem.
JIN DUN Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom muaj txiaj ntsig, ua kom zoo, nruj, thiab tawm mus ua ib tus neeg ntseeg siab thiab phooj ywg ntawm cov neeg siv khoom!
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