Rivaroxaban (S)-Rivaroxaban; BAY 59-7939; RivaroxabanIsomer; Rivaroxaban;
Rivaroxaban (S)-Rivaroxaban; BAY 59-7939; RivaroxabanIsomer; Rivaroxaban;
Siv nyob rau hauv cov neeg laus uas muaj kev xaiv ntawm lub duav los yog lub hauv caug hloov phais los tiv thaiv venous thrombosis (VTE).
Nws yog siv los tiv thaiv los yog txo qhov tsim ntawm thrombosis, tob vein thrombosis (DVT) thiab pulmonary embolism (PE) tom qab lub duav los yog lub hauv caug hloov phais.
Cov koob tshuaj pom zoo yog qhov ncauj rivaroxaban 10mg, ib hnub ib zaug.Rivaroxaban 10mg tuaj yeem noj nrog zaub mov lossis ib leeg.Rivaroxaban 15mg lossis 20mg ntsiav tshuaj yuav tsum tau noj nrog zaub mov.
xwm: usp40
Kev Ntsuas: 99-102%
Sab nrauv: Dawb hmoov
Pob: 25kg / nruas
Siv 4-(4-aminophenyl) morpholin-3-one (SM-1), (S)-N-glycidyl phthalimide (SM-2), 5-chlorothiophene-2- Formyl chloride (SM-3) yog cov khoom pib .Tom qab condensation, cyclization, aminolysis thiab acylation, crude rivaroxaban yog tau, thiab cov tiav rivaroxaban yog refined.
Kev npaj: Cov khoom no yog cov ntsiav tshuaj liab zaj duab xis-coated.
Accessories:
Cov ntsiav tshuaj: microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, hypromellose, sodium lauryl sulfate, magnesium stearate
Txheej: polyethylene glycol, hypromellose, titanium dioxide, hlau oxide liab
Rivaroxaban yog ib qho kev xaiv zoo heev, qhov ncauj tshuaj uas ncaj qha inhibits yam Xa.Los ntawm kev xaiv ntau thiab kev sib tw inhibition ntawm kev pub dawb thiab khi yam tseem ceeb Xa thiab prothrombin kev ua, ncua lub sijhawm ua haujlwm ib nrab thromboplastin lub sij hawm phaj (PT) thiab prothrombin lub sij hawm (aPTT) nyob rau hauv ib koob tshuaj, uas tuaj yeem cuam tshuam cov coagulation dej tsaws tsag Txoj hauv kev endogenous thiab exogenous. inhibit zus tau tej cov thrombin thiab thrombosis.Rivaroxaban tsis inhibit thrombin (ua kom muaj txiaj ntsig Ⅱ), thiab nws tsis muaj pov thawj tias muaj kev cuam tshuam rau platelets.
Qhov sib txawv tseem ceeb ntawm rivaroxaban thiab fondaparinux / heparin yog tias nws tsis tas yuav muaj kev koom tes ntawm antithrombin III thiab tuaj yeem tiv thaiv ncaj qha rau cov khoom dawb thiab khi rau Xa;thaum heparin xav tau antithrombin III ua haujlwm, thiab Nws tsis muaj qhov cuam tshuam rau Xa hauv cov prothrombin complex.
JIN DUN Medical muajISO tsim nyog thiab ua tau raws li GMP cov qauv tsim, ua hauj lwm hauv tsev thiab txawv teb chaws cov kws kho tshuaj synthesis nrog kev nplua nuj los coj lub tuam txhab R & D.
TECHNOL OGY ADVANTAGES
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction.Cryogenic cov tshuaj tiv thaiv (<-78% C)
●Aromatic Heterocyclic Synthesis
● Kev Ruaj Ntseg Tsis Zoo
● Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Gignard Reaction
Cov khoom siv
Peb lub Lab muaj ntau yam kev sim thiab ntsuas cov cuab yeej, xws li: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope ...
Pab neeg R&D
Jindun Kev Kho Mob muaj ib pab pawg kws tshaj lij R & D cov neeg ua haujlwm, thiab ntiav ntau tus kws tshaj lij kev siv tshuaj hauv tsev thiab txawv teb chaws los coj R&D, ua rau peb cov khoom sib xyaw ua kom raug thiab ua tau zoo.
Peb tau pab ntau lub tuam txhab tshuaj hauv tsev sab saum toj, xws liHansoh, Hengrui thiab HEC Pharm.Ntawm no peb yuav qhia ib feem ntawm lawv.
Customzation Case Ib:
CAS Nr .: 110351-94-5
Customzation Case Ob:
CAS Nr .: 144848-24-8
Customzation Case Peb:
CAS Nr .: 200636-54-0
1.Customize New Intermediates lossis APIs.Ib yam li cov ntaub ntawv sib qhia saum toj no, cov neeg siv khoom muaj qhov xav tau tshwj xeeb Intermediates lossis APIs, thiab lawv nrhiav tsis tau cov khoom xav tau hauv khw, ces peb tuaj yeem pab kho.
2.Txheej txheem Optimization rau cov khoom qub.Peb pab neeg yuav pab Optimize thiab txhim kho xws li ntau lawm uas nws cov tshuaj tiv thaiv txoj kev yog qub, ntau lawm nqi yog siab, thiab efficiency yog tsawg.Peb tuaj yeem muab cov ntaub ntawv tag nrho rau kev hloov pauv thev naus laus zis thiab kev txhim kho cov txheej txheem, pab cov neeg siv khoom kom muaj txiaj ntsig ntau dua.
Los ntawm cov hom phiaj tshuaj rau INDs, JIN DUN Kev Kho Mob muab rau kojib-nres tus kheej R & D kev daws teeb meem.
JIN DUN Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom muaj txiaj ntsig, ua kom zoo, nruj, thiab tawm mus ua ib tus neeg ntseeg siab thiab phooj ywg ntawm cov neeg siv khoom!
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