Lag luam wholesale Kub Muag Ibrutinib Intermediates N-3 CAS 330792-70-6

Nrog rau cov lus qhia hauv siab no, peb tam sim no tau dhau los ua ib qho ntawm feem ntau cov thev naus laus zis tshiab, tus nqi tsim nyog, thiab cov nqi sib tw rau cov lag luam wholesale Kub Muag Ibrutinib Intermediates N-3 CAS 330792-70-6, Peb tos ntsoov rau muab koj nrog peb cov khoom nyob rau hauv lub neej yav tom ntej, thiab koj yuav pom peb hais yog heev tsim nyog thiab qhov zoo ntawm peb cov khoom yog heev zoo heev!
Nrog rau cov lus qhia hauv siab no, peb tam sim no tau dhau los ua ib qho ntawm cov khoom siv thev naus laus zis tshaj plaws, tus nqi tsim nyog, thiab tus nqi sib tw rau cov tuam txhab.Tuam Tshoj Ibrutinib N-3 thiab Intermediates, Txog tam sim no peb cov khoom tau raug xa tawm mus rau sab hnub tuaj Europe, Middle East, Southeast, Africa thiab South America thiab lwm yam. Peb muaj 13years kev muag khoom thiab kev yuav khoom hauv Isuzu qhov chaw hauv tsev thiab txawv teb chaws thiab cov tswv cuab ntawm cov khoom siv hluav taws xob niaj hnub Isuzu qhov chaw kuaj xyuas.Peb hwm peb tus thawj tswj hwm ntawm Kev Ncaj Ncees hauv kev lag luam, qhov tseem ceeb hauv kev pabcuam thiab yuav ua peb qhov zoo tshaj plaws los muab peb cov neeg siv khoom nrog cov khoom zoo thiab cov kev pabcuam zoo.

Intermediate rau kev sib txuas ntawm allopurinol.

Nws yog ib qho ntawm 3-amino-4-substituted pyrazole series.Nws tuaj yeem siv los ua ib qho nruab nrab los ua kom muaj ntau yam tshuaj muaj txiaj ntsig zoo ntawm cov organic sib txuas, xws li allopurinol, ib qho ntawm pyrazolopyrimidine derivatives series, tom kawg txij li xyoo 1963 Txij li thaum nws siv tshuaj kho mob, nws yog cov tshuaj tseem ceeb rau kev kho mob gout.Tam sim no, muaj ob peb txoj kev paub rau kev sib txuas

3-aminopyrazole-4-carboxamide hemisulfate nyob rau hauv Suav teb, feem ntau yog los ntawm reacting malononitrile thiab triethyl orthoformate los npaj ethoxymethylene malononitrile, thiab tom qab ntawd nrog cov tshuaj tiv thaiv ntawm hydrazine hydrate yields 3-amino-4-cyanopyrazole, uas yog thaum kawg reacted sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), tag nrho cov txiaj ntsig ntawm synthesis los ntawm txoj kev no yog kwv yees li 60% (xws li malononitrile), txoj kev no Nws muaj peb-kauj ruam cov tshuaj tiv thaiv, cov kauj ruam ntev dua, thiab cov reagents siv, xws li malononitrile thiab ethoxymethylene malononitrile, muaj tshuaj lom thiab kim dua.Tsis tas li ntawd, 3-aminopyrazole-4 npaj los ntawm txoj kev no -Formamide hemisulfate muaj xim uas nyuaj rau tshem tawm thiab yuav tsum tau ua ntxiv, uas yog qhov nyuaj dua.

Muaj cov ntawv ceeb toom nyob rau hauv cov ntaub ntawv txawv teb chaws siv pyridylamide hydrazone thiab ethoxymethylene malononitrile ua raw khoom kom tau 3-amino-4-cyanopyrazole los ntawm kev ntxiv thiab cyclization, thiab tom qab ntawd hnov ​​mob nrog cov concentrated sulfuric acid kom tau lub hom phiaj compound (Reuken G Jones. Reactions of orthoesters with activemethylene compounds[J].J Am Chem Soc. 1952,74(5):4889 4891).Cov ntaub ntawv tseem ceeb siv rau hauv txoj kev no yog kim, cov tshuaj tiv thaiv tawm los tsis siab, thiab cov txiaj ntsig ntawm kev lag luam yog tsawg.Nws yuav tsum nyuaj.

Executive standard:Enterprise Standard
Sab nrauv:Off-dawb los yog daj hmoov

Pob:25kg / nruas
assay (HPLC) cov ntsiab lus Ntau dua lossis sib npaug rau 98.0%
purity (HPLC) cov ntsiab lus Ntau dua lossis sib npaug rau 99.5%

JIN DUN Medical muajISO tsim nyog thiab ua tau raws li GMP cov qauv tsim, ua hauj lwm hauv tsev thiab txawv teb chaws cov kws kho tshuaj synthesis nrog kev nplua nuj los coj lub tuam txhab R & D.

TECHNOL OGY ADVANTAGES
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction.Cryogenic cov tshuaj tiv thaiv (<-78% C)
●Aromatic Heterocyclic Synthesis
● Kev Ruaj Ntseg Tsis Zoo
● Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Gignard Reaction

Cov khoom siv

Peb lub Lab muaj ntau yam kev sim thiab ntsuas cov cuab yeej, xws li: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope…

Pab neeg R&D

Jindun Kev Kho Mob muaj ib pab pawg kws tshaj lij R & D cov neeg ua haujlwm, thiab ntiav ntau tus kws tshaj lij kev siv tshuaj hauv tsev thiab txawv teb chaws los coj R&D, ua rau peb cov khoom sib xyaw ua kom raug thiab ua tau zoo.

Peb tau pab ntau lub tuam txhab tshuaj hauv tsev sab saum toj, xws liHansoh, Hengrui thiab HEC Pharm.Ntawm no peb yuav qhia ib feem ntawm lawv.

Customzation Case Ib:

CAS Nr .: 110351-94-5

Customzation Case Ob:

CAS Nr .: 144848-24-8

Customzation Case Peb:

CAS Nr .: 200636-54-0

1.Customize New Intermediates lossis APIs.Ib yam li cov ntaub ntawv sib qhia saum toj no, cov neeg siv khoom muaj qhov xav tau tshwj xeeb Intermediates lossis APIs, thiab lawv nrhiav tsis tau cov khoom xav tau hauv khw, ces peb tuaj yeem pab kho.

2.Txheej txheem Optimization rau cov khoom qub.Peb pab neeg yuav pab Optimize thiab txhim kho xws li ntau lawm uas nws cov tshuaj tiv thaiv txoj kev yog qub, ntau lawm nqi yog siab, thiab efficiency yog tsawg.Peb tuaj yeem muab cov ntaub ntawv tag nrho rau kev hloov pauv thev naus laus zis thiab kev txhim kho cov txheej txheem, pab cov neeg siv khoom kom muaj txiaj ntsig ntau dua.

Los ntawm cov hom phiaj tshuaj rau INDs, JIN DUN Kev Kho Mob muab rau kojib-nres tus kheej R & D kev daws teeb meem.

JIN DUN Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom muaj txiaj ntsig, ua kom zoo, nruj, thiab tawm mus ua ib tus neeg ntseeg siab thiab phooj ywg ntawm cov neeg siv khoom!

Nrog rau cov lus qhia hauv siab no, peb tam sim no tau dhau los ua ib qho ntawm feem ntau cov thev naus laus zis tshiab, tus nqi tsim nyog, thiab cov nqi sib tw rau cov lag luam wholesale Kub Muag Ibrutinib Intermediates N-3 CAS 330792-70-6, Peb tos ntsoov rau muab koj nrog peb cov khoom nyob rau hauv lub neej yav tom ntej, thiab koj yuav pom peb hais yog heev tsim nyog thiab qhov zoo ntawm peb cov khoom yog heev zoo heev!
Lag luam wholesaleTuam Tshoj Ibrutinib N-3 thiab Intermediates, Txog tam sim no peb cov khoom tau raug xa tawm mus rau sab hnub tuaj Europe, Middle East, Southeast, Africa thiab South America thiab lwm yam. Peb muaj 13years kev muag khoom thiab kev yuav khoom hauv Isuzu qhov chaw hauv tsev thiab txawv teb chaws thiab cov tswv cuab ntawm cov khoom siv hluav taws xob niaj hnub Isuzu qhov chaw kuaj xyuas.Peb hwm peb tus thawj tswj hwm ntawm Kev Ncaj Ncees hauv kev lag luam, qhov tseem ceeb hauv kev pabcuam thiab yuav ua peb qhov zoo tshaj plaws los muab peb cov neeg siv khoom nrog cov khoom zoo thiab cov kev pabcuam zoo.