3-(1-(Dimethylamino)ethyl]phenol
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3-(1-(Dimethylamino)ethyl]phenol
3-(1-(Dimethylamino)ethyl] phenol yog siv los ua qhov nruab nrab ntawm Rivastigmine tartrate .
Rivastigmine tartrate yog rivastigmine Alzheimer's kab mob tshuaj, rivastigmine yog physostigmine derivative los ntawm Novartis thawj zaug ntse tsim lub npe lag luam Exelon (exelon), molecule nrog muaj carbamate qauv, yog ib yam ntawm cov amino acid ntawm xaiv cerebral cholinesterase inhibitor, kuj inhibitor. acetylcholinesterase thiab butyrylcholinesterase, cholinergic neurons los ntawm ncua kev tso tawm ntawm acetylcholine degradation thiab lub zog txhawb nqa cholinergic paj hlwb, tuaj yeem txhim kho kev paub txog kev ua haujlwm tsis zoo los ntawm cholinergic, yog li txhim kho kev paub txog kev ua haujlwm ntawm Alzheimer's cov neeg mob.Rivastigmine plasma protein binding tsis muaj zog, yooj yim los ntawm cov ntshav-hlwb barrier, uas muaj lub siab ntawm lub hlwb xaiv.Nws tsis tsuas yog xaiv tau yooj yim tshaj plaws cuam tshuam rau cerebral cortex thiab hippocampus, tab sis kuj nyiam inhibits qhov tseem ceeb ntawm AChE hauv lub hlwb, uas ua rau txo qis kev ua tau zoo ntawm peripheral cholinergic phiv.Rivastigmine hauv vivo ib nrab-lub neej yog luv thiab ntev ntawm kev ua.Tsis zoo li tacrine, cov khoom no nyob rau hauv hippocampus thiab cortex ntawm G1 enzyme inhibitory nyhuv muaj zog dua.Clinic rau kev kho mob me me mus rau nruab nrab Alzheimer-type dementia, lossis Alzheimer's disease tuaj yeem xav tias Alzheimer's kab mob hauv tsev kho mob.
JIN DUN Medical muajISO tsim nyog thiab ua tau raws li GMP cov qauv tsim, ua hauj lwm hauv tsev thiab txawv teb chaws cov kws kho tshuaj synthesis nrog kev nplua nuj los coj lub tuam txhab R & D.
TECHNOL OGY ADVANTAGES
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction.Cryogenic cov tshuaj tiv thaiv (<-78% C)
●Aromatic Heterocyclic Synthesis
● Kev Ruaj Ntseg Tsis Zoo
● Chiral Resolution
●Heck, Suzuki, Negishi, Sonogashira .Gignard Reaction
Cov khoom siv
Peb lub Lab muaj ntau yam kev sim thiab ntsuas cov cuab yeej, xws li: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope ...
Pab neeg R&D
Jindun Kev Kho Mob muaj ib pab pawg kws tshaj lij R & D cov neeg ua haujlwm, thiab ntiav ntau tus kws tshaj lij kev siv tshuaj hauv tsev thiab txawv teb chaws los coj R&D, ua rau peb cov khoom sib xyaw ua kom raug thiab ua tau zoo.
Peb tau pab ntau lub tuam txhab tshuaj hauv tsev sab saum toj, xws liHansoh, Hengrui thiab HEC Pharm.Ntawm no peb yuav qhia ib feem ntawm lawv.
Customzation Case Ib:
CAS Nr .: 110351-94-5
Customzation Case Ob:
CAS Nr .: 144848-24-8
Customzation Case Peb:
CAS Nr .: 200636-54-0
1.Customize New Intermediates lossis APIs.Ib yam li cov ntaub ntawv sib qhia saum toj no, cov neeg siv khoom muaj qhov xav tau tshwj xeeb Intermediates lossis APIs, thiab lawv nrhiav tsis tau cov khoom xav tau hauv khw, ces peb tuaj yeem pab kho.
2.Txheej txheem Optimization rau cov khoom qub.Peb pab neeg yuav pab Optimize thiab txhim kho xws li ntau lawm uas nws cov tshuaj tiv thaiv txoj kev yog qub, ntau lawm nqi yog siab, thiab efficiency yog tsawg.Peb tuaj yeem muab cov ntaub ntawv tag nrho rau kev hloov pauv thev naus laus zis thiab kev txhim kho cov txheej txheem, pab cov neeg siv khoom kom muaj txiaj ntsig ntau dua.
Los ntawm cov hom phiaj tshuaj rau INDs, JIN DUN Kev Kho Mob muab rau kojib-nres tus kheej R & D kev daws teeb meem.
JIN DUN Kev Kho Mob hais kom tsim ib pab neeg nrog kev npau suav, ua cov khoom muaj txiaj ntsig, ua kom zoo, nruj, thiab tawm mus ua ib tus neeg ntseeg siab thiab phooj ywg ntawm cov neeg siv khoom!
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