3-Amino-4-pyrazole carbosamide hemisulfate

Intermediate rau kev sib txuas ntawm allopurinol.

Nws yog ib qho ntawm 3-amino-4-substituted pyrazole series.Nws tuaj yeem siv los ua ib qho nruab nrab los ua kom muaj ntau yam tshuaj muaj txiaj ntsig zoo ntawm cov organic sib txuas, xws li allopurinol, ib qho ntawm pyrazolopyrimidine derivatives series, tom kawg txij li xyoo 1963 Txij li thaum nws siv tshuaj kho mob, nws yog cov tshuaj tseem ceeb rau kev kho mob gout.Tam sim no, muaj ob peb txoj kev paub rau kev sib txuas

3-aminopyrazole-4-carboxamide hemisulfate nyob rau hauv Suav teb, feem ntau yog los ntawm reacting malononitrile thiab triethyl orthoformate los npaj ethoxymethylene malononitrile, thiab tom qab ntawd nrog cov tshuaj tiv thaiv ntawm hydrazine hydrate yields 3-amino-4-cyanopyrazole, uas yog thaum kawg reacted sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), tag nrho cov txiaj ntsig ntawm synthesis los ntawm txoj kev no yog kwv yees li 60% (xws li malononitrile), txoj kev no Nws muaj peb-kauj ruam cov tshuaj tiv thaiv, cov kauj ruam ntev dua, thiab cov reagents siv, xws li malononitrile thiab ethoxymethylene malononitrile, muaj tshuaj lom thiab kim dua.Tsis tas li ntawd, 3-aminopyrazole-4 npaj los ntawm txoj kev no -Formamide hemisulfate muaj xim uas nyuaj rau tshem tawm thiab yuav tsum tau ua ntxiv, uas yog qhov nyuaj dua.

Muaj cov ntawv ceeb toom nyob rau hauv cov ntaub ntawv txawv teb chaws siv pyridylamide hydrazone thiab ethoxymethylene malononitrile ua raw khoom kom tau 3-amino-4-cyanopyrazole los ntawm kev ntxiv thiab cyclization, thiab tom qab ntawd hnov ​​mob nrog cov concentrated sulfuric acid kom tau lub hom phiaj compound (Reuken G Jones. Reactions of orthoesters with activemethylene compounds[J].J Am Chem Soc. 1952,74(5):4889 4891).Cov ntaub ntawv tseem ceeb siv rau hauv txoj kev no yog kim, cov tshuaj tiv thaiv tawm los tsis siab, thiab cov txiaj ntsig ntawm kev lag luam yog tsawg.Nws yuav tsum nyuaj.